HCRT and Cataplexy: Furthermore, a 7-day chronic blockade of Hcrt/Ox transmission with dual orexin receptor antagonists (DORAs) in wild type mice (Mahoney et al., 2020; Kaushik et al., 2021) produces REM sleep-related narcoleptic symptoms -such as cataplexy- after exposure to certain stimuli, as is observed in human NT1 (Schiappa et al., 2018).