These data indicated that HIF-3α can upregulate the transcriptional levels of cancer-related genes, including ETV1, ETV5, ETV4, CXCL8, HMGA2, IL6, DUSP6, ARNT2, PTGS2, SOCS3, CCL5, FOS, JUN, IL6, and VEGFC (Figure 2(e)). This evidence concerns the gene SOCS3 and cancer.