NR3C1 and bipolar disorder: For instance, Perroud et al. (2011) reported a significant difference in methylation levels at the glucocorticoid receptor, NR3C1, with history of sexual abuse in patients with bipolar disorder: those without a history of sexual abuse had methylation levels of 0.128 (s.d. 0.02), whereas those who had experienced sexual abuse had methylation levels of 0.141 (s.d. 0.02) (Perroud et al. 2011).