Although NFTs are a hallmark of tauopathies and have been largely pointed as a causal of disease (Spires-Jones et al., 2011), it is also noteworthy that the lack of normal tau function might also underlie neuronal dysfunction, with the consequent manifestation of clinical signs of dementia (Avila, 2009; Medina et al., 2016; Catarina Silva and Haggarty, 2020). This evidence concerns the gene MAPT and dementia.