To investigate the immunohistochemical profile of the two tumors, 16 markers were selected, including the neuroendocrine markers synaptophysin (Syn), neuron-specific enolase (NSE), chromaffin granule protein A (CgA), and CD56; somatostatin receptor 2 (SSTR2); classically mutated genes in the two tumors including β-catenin, ATRX, and DAXX; and pancreatic neoplasms markers including trypsin, chymotrypsin, vimentin, and CD10. The gene discussed is ENO2; the disease is pancreatic neoplasm.