SEC61A1 and type 2 diabetes mellitus: Interestingly, deletion of ERj6, one of the proteins assisting BiP in its regulation of Sec61 complex-mediated Ca2+ leakage, results in both mice (Ladiges et al., 2005) and humans (Synofzik et al., 2014) in pancreatic β cell failure and T2D, suggesting that increased Ca2+ leakage might form part of the mechanism involved.