SEC61A1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: This was similar to the depletion observed when expressing in the same cells SEC61A1-V67G or SEC61A1-T185A, two heterozygous missense mutations already shown to result in autosomal-dominant tubulo-interstitial kidney disease (ADTKD) (Bolar et al., 2016).