To investigate the relevance of palmitoylation as a modification in heart failure, using the available data, we plotted the change in relative abundance in HFpEF and HFrEF compared to organ donor controls of all available palmitoylating enzymes (zDHHC-PATs), depalmitoylating enzymes (LYPLAs, PPTs and ABHDs), accessory proteins [Selenoprotein-K (Fredericks et al., 2017) and Golga7 (Ko et al., 2019)] and proteins involved in fatty acyl CoA production [acyl-CoA synthases (ACSL) and fatty acid synthase (FASN)]. The gene discussed is SELENOK; the disease is heart failure.