Previous studies have indicated that TMEM16A expression is strongly expressed in the kidneys of patients with IgA nephropathy, renal cyst models and mice with high-fat diet/streptozotocin-induced diabetic nephropathy (Buchholz et al., 2014; Lian et al., 2017; Li et al., 2022a), suggesting an important role for TMEM16A in kidney disease. This evidence concerns the gene ANO1 and cystic kidney disease.