CLCN5 and renal fibrosis: In contrast, Yang’s group showed that mice with ClC-5 upregulation using a specialized adeno-associated virus vector largely protected against the development of renal fibrosis and inflammatory lesions after unilateral ureteral obstruction (UUO), and restored E-cadherin synthesis and reduced vimentin, α-SMA, and collagen fibril expression in the renal cortex (Yang et al., 2019b).