It has been reported that TRPC6 channels regulate CXC chemokine receptor 2 (CXCR2)-related chemotaxis by mediating Ca2+ influx (Lindemann et al., 2013), promoting renal tubular cell senescence and renal fibrosis by inducing mitochondrial dysfunction (Meng et al., 2022). The gene discussed is CXCR2; the disease is renal fibrosis.