They also indicated that KCa3.1 was upregulated in fibrotic kidneys of mice induced by UUO, and again KCa3.1-deficient mice or mice treated with TRAM-34 markedly reduced the number of myofibroblasts and delayed renal fibrosis in mice after ureteral obstruction when compared to control mice (Grgic et al., 2009a). The gene discussed is KCNN4; the disease is Ureteral obstruction.