Although a plethora of literature with in-depth and extensive mechanistic research, unfortunately there is no effective treatment for renal fibrosis, and the only proven method to slow the decline of renal function remains blockade of the renin-angiotensin system with angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers, or renin inhibitors (Francois and Chatziantoniou, 2018). This evidence concerns the gene REN and renal fibrosis.