They also indicated that KCa3.1 was upregulated in fibrotic kidneys of mice induced by UUO, and again KCa3.1-deficient mice or mice treated with TRAM-34 markedly reduced the number of myofibroblasts and delayed renal fibrosis in mice after ureteral obstruction when compared to control mice (Grgic et al., 2009a). Here, KCNN4 is linked to renal fibrosis.