CFTR and renal fibrosis: Interestingly, CFTR expression was downregulated in the UUO mouse model and human fibrotic kidney, and the UUO-induced deltaF508 fibrosis mouse model has significantly higher β-catenin protein activity and renal fibrosis aggregation, which can be rescued by overexpression of CFTR, implying that CFTR regulation appears to be a potential therapeutic target for anti-fibrosis via Wnt/β-catenin signaling (Zhang et al., 2017).