CFTR and renal fibrosis: In the kidney, the mouse δF508 CFTR mutation exacerbates the fibrotic phenotype induced by unilateral ureteral obstruction (UUO), which is a well-established animal model of renal fibrosis, and in vitro, inhibition of CFTR activity using the inhibitors inh-172 or GlyH101 is sufficient to trigger the EMT process in renal cells (Zhang et al., 2017).