SLC9A1 and glomerulosclerosis: Another study stresses the critical role of NHE-1 in an adriamycin (ADR)-induced glomerulosclerosis rat model, where NHE-1 mRNA expression was significantly enhanced, and high sodium diet accelerated interstitial fibrosis and further increased NHE1 expression, this effect could be prevented by amiloride (although not a specific NHE1 inhibitor) (Okuda et al., 1994).