Besides, another study indicated that CUG-BP (also known as CELF1)/RBFox2 can be phosphorylated and up-regulated by activating PKC signaling in diabetic heart, which in turn alters the AS of gene and contribute to diabetic cardiomyopathy pathogenesis (Verma et al., 2013). Here, RBFOX2 is linked to diabetic cardiomyopathy.