GH1 and hydrops fetalis: The decrease in the hepatic mRNA levels of most of the genes of the axis (mainly igf-1, igfbp-2 and igfbp-4) in the HF + HT dietary groups, but also in the HF_RE group, could be the result of a negative feedback inhibition from circulating IGF-1 after continued signaling by this hormone, as a mechanism to sustain GH/IGF system homeostasis.