In addition, TRPV1 is cardio-protective against ischemia, since TRPV1 null-mutant mice are more susceptible to myocardial infarction-induced, TGF-β1/Smad2-mediated myofibroblast activation and fibrinogenesis (Huang et al., 2010). The gene discussed is TRPV1; the disease is ischemia.