TRPV1 and myocardial infarction: In contrast to profibrotic effects, TRPV1 has also been shown to be cardioprotective against post myocardial infarction, since TRPV1 null-mutant mice had a reduced ejection fraction and a high mortality rate, and were more susceptible to myofibroblast activation and fibrinogenesis (Huang et al., 2010).