In addition, TRPC6 has been proposed to be essential for the protective scar formation of the cardiac chamber post myocardial infarction, given that the hearts of TRPC6 null-mutant mice had a smaller protective wall scar and were prone to cardiac rupture and ventricular dilatation as well as to poor functional recovery (Davis et al., 2012). This evidence concerns the gene TRPC6 and Ventriculomegaly.