TRPC6 and myocardial infarction: In addition, TRPC6 has been proposed to be essential for the protective scar formation of the cardiac chamber post myocardial infarction, given that the hearts of TRPC6 null-mutant mice had a smaller protective wall scar and were prone to cardiac rupture and ventricular dilatation as well as to poor functional recovery (Davis et al., 2012).