As one of the most common SNP of ERCC1, rs11615 polymorphism, a base substitution of ancestral allele C to mutation allele T, has been demonstrated that modify the risk for various cancers, for example, non-small-cell lung cancer, glioma and meningioma, esophageal adenocarcinoma, and gynecology tumors like ovarian and cervical cancer [12–17]. Here, ERCC1 is linked to cancer.