In the study, it was found that the level of inflammatory indexes in the patients treated with Xiyanping adjuvant therapy was significantly lower than that in the patients treated with conventional therapy, suggesting that Xiyanping could regulate GDF-15 and HIF-1α to other inflammatory-related factors and reduce the inflammatory response of the body, which was one of the important mechanisms in the treatment of acute exacerbation of COPD in the elderly by detecting the above inflammatory indexes. The gene discussed is HIF1A; the disease is chronic obstructive pulmonary disease.