The key targets of Xiebai Powder combined with azithromycin in the treatment of pneumonia were mainly TNF, IL-6, ALB, AKT1, IL-1Β, TP53, CASP3, PTGS2, JUN, STAT3, etc. Among them, both TNF and IL-6 are inflammatory factors. The gene discussed is TP53; the disease is susceptibility to pneumonia measurement.