For example, many SOD1 mutations can cause amyotrophic lateral sclerosis (ALS) (Sau et al., 2007), NF1 mutations can cause pediatric brain tumors (Campian and Gutmann, 2017), RB1 mutations can cause retinoblastoma (Yun et al., 2011), and ETV6 mutations can cause pediatric acute lymphoblastic leukemia (Hock and Shimamura, 2017). The gene discussed is RB1; the disease is amyotrophic lateral sclerosis.