SOD1 and amyotrophic lateral sclerosis: For example, many SOD1 mutations can cause amyotrophic lateral sclerosis (ALS) (Sau et al., 2007), NF1 mutations can cause pediatric brain tumors (Campian and Gutmann, 2017), RB1 mutations can cause retinoblastoma (Yun et al., 2011), and ETV6 mutations can cause pediatric acute lymphoblastic leukemia (Hock and Shimamura, 2017).