Biological functions, such as the focal adhesion-PI3K-AKT-mTOR signaling pathway (Figure 5A), extracellular matrix organization (Figure 5B), and tyrosine metabolism (Figure 5C), were remarkably enriched in the low-risk group, while other biological functions, such as DNA mismatch repair (Figure 5D), CTLA4 inhibitory signaling (Figure 5E), primary immunodeficiency (Figure 5F), DNA replication (Figure 5G), allograft rejection (Figure 5H), and the G2 pathway (Figure 5I), were strikingly concentrated in the high-risk group (Supplementary Material S2). The gene discussed is CTLA4; the disease is inborn error of immunity.