PON1 and osteoarthritis: A previous study found that the RS1501299 polymorphism of the Adipoq increases the risk of knee osteoarthritis (Shang et al., 2019), and the interaction between the rs1501299 (Adipoq) and rs662 (Pon1) gene polymorphisms may play an important role in the development of osteoarthritis (Fernandez-Torres et al., 2019).