EZH2 and myeloproliferative neoplasm: Even though EZH2 overexpression and gain-of-function present oncogenic activity, EZH2 also plays a crucial role in tumor suppression, such as myelodysplastic syndromes, myeloproliferative neoplasms, and T cell acute lymphoblastic leukemia (Ernst et al., 2010; Nikoloski et al., 2010; Ntziachristos et al., 2012).