EZH2 and uveal melanoma: Jin et al. (2020) found that overexpression of EZH2 promoted the growth, migration, and invasion of UM. Our study investigated the association between EZH2 and H3K27me3 expression and prognosis. With the development of selective EZH2 inhibitors, we attempt to reveal the roles of EZH2 and H3K27me3 in uveal melanoma via small-molecule EZH2 inhibitors, including GSK126, GSK503, EED226, UNC1999, and EZP6438.