Upon investigating the regulatory mechanism of MHC-I in DLBCL, we found that B2M expression in the training set was significantly higher in subtype C1 than in subtype C2 (p < 0.001), and EZH2 expression was even more highly expressed in subtype C2 (p < 0.001; Figures 6A,B). Here, B2M is linked to diffuse large B-cell lymphoma.