ERBB2 and gastric cancer: Sung et al.,2021 assessed the association of CT texture with outcome of GC patients received Trastuzumab treatment. However, this study only investigated the texture features extracted from the largest cross-sectional area of lesions (Yoon et al., 2016). In line with previous reports, we found that entropy was a crucial feature for prediction of HER2 status (Waugh et al., 2016). In addition, Grey Level Nonuniformity, which was selected in our signature, was suggested to be an important feature for measuring intratumoral heterogeneity (Aerts et al., 2014).