PHF8 and diabetes mellitus: In the present study, we observed a significant increase in LSD1 and PHF8 levels as well as in H3K4me2 and H3K4me3 demethylation levels in the presence of riboglycated BSA (1.5 μM final concentration) but not in the presence of glucoglycated BSA, suggesting that the riboglycated protein plays a role in the progression of diabetes with an epigenetic dysmetabolic disorder.