Furthermore, we investigated the co-expression survival analysis of CD274 and PDCD1LG2 in pan-cancer and found that both low expression of CD274 and PDCD1LG2 had better prognosis in ACC (p < 0.019) (Figure 4J) and SKCM (p < 0.001) (Figure 4L), and both high expression of CD274 and PDCD1LG2 had worse prognosis in LGG (p < 0.001) (Figure 4K). The gene discussed is CD274; the disease is cancer.