More importantly, we found that patients with high expression of CD274 and PDCD1LG2 had better overall survival in ACC and SKCM, and patients with high expression of CD274 and PDCD1LG2 had worse overall survival in LGG, we suggested that integrate CD274 and PDCD1LG2 could better predict the prognosis in these cancers. Here, CD274 is linked to cancer.