CCK8 (Figures 5(a)-5(b)) and cloning formation assays showcased that HK2 overexpression or miR-590-5p suppression reversed CRC cell proliferation in Lovo and SW480 cells after circ-PITHD1 silencing (Figures 5(c)–5(e)). The gene discussed is PITHD1; the disease is colorectal carcinoma.