SREBF2 and glioblastoma: Based on our analysis of the CGGA database, in tumor tissues of GBM patients treated with TMZ, the level of LXRα mRNA (NR1H3) was associated with prolonged survival, while the level of the raft resistance gene MDR1 was negatively correlated with NR1H3 and positively correlated with cholesterol uptake gene LDLR and synthetic gene SREBF2. It was recently reported that cholesterol accumulation mediated by the downregulation of LXRα promoted GBM cell growth, whereas the activation of LXRα-mediated cholesterol efflux exhibited the opposite effects [19, 44].