NR1H3 and glioma: By comparing the levels of cholesterol metabolism genes in high-grade glioma (HGG, WHO III-IV) tissues of patients receiving TMZ therapy with OS less than half a year and 5 years (Supplementary Figure S4(a)), we found that the level of NR1H3 (transcribing LXRα) mRNA that mediates cholesterol efflux in patients with longer survival is higher than that with shorter survival.