GAPDH and neoplasm: HIF-1α, in collaboration with c-Myc, promotes glucose uptake by cells and accelerates tumor cell aerobic glycolysis by increasing the expression of GLUTs (primarily GLUT1 and GLUT3) or additional glycolytic enzymes that rely on HIF-1α (such as LDHA, MCT4, and GAPDH) [108, 109].