For instance, a double-blinded randomized placebo-controlled trial (RCT) among 30 pairs of PCOS patients and controls aged 18–40 years old suggested that a 12-week linseed oil omega-3 PUFAs supplementation (rich in DHA + EPA) significantly reduced insulin values and HOMA-IR, but increased insulin sensitivity check index (all P-values < 0.05) (17). The gene discussed is INS; the disease is polycystic ovary syndrome.