IGHE and dermatitis herpetiformis: The non-IgE-mediated, among which CD has been already analyzed, forms include also (a) eosinophil esophagitis, (b) eosinophil gastritis, and (c) dermatitis herpetiformis, where the eosinophilic pathologies are mediated by activation of innate immunity through IL-C2 activity, in contrast to CD and dermatitis herpetiformis which are caused by an immune-mediated mechanism.