Induced lysosomal membrane permeabilization by downregulating mTOR signal and releasing lysosomal cell death protein Cathepsin D lead ERK1/2, p38 MAPKs activation via ROS and BH3-only Bad increase, and Bcl-xL decrease in autophagy mediated cell death in AGS gastric cancer cells (85). This evidence concerns the gene BCL2L1 and gastric cancer.