Based on the findings of Perry et al. the elevation of IL-6 is more sensitive than any other inflammatory mediators in plasma and adipose tissue macrophages in HFD-fed mice (2), as well as emerging evidence that IL-6 is an important mediator under adipose tissue inflammation-related lipolysis in obesity (24–27), we then focused on the effect of Phillyrin treatment on IL-6 in WAT. This evidence concerns the gene IL6 and obesity disorder.