Based on the findings of Perry et al. the elevation of IL-6 is more sensitive than any other inflammatory mediators in plasma and adipose tissue macrophages in HFD-fed mice (2), as well as emerging evidence that IL-6 is an important mediator under adipose tissue inflammation-related lipolysis in obesity (24–27), we then focused on the effect of Phillyrin treatment on IL-6 in WAT. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.