MYCN and neoplasm: As summarized in Table 1, these patients had the typical characteristics of high-risk NB: 85% (17/20) were ≧18 months old, 95% (19/20) with INRG stage M, 50% (10/20) with MYCN-amplified tumor, 95% (19/20) with BM metastasis at diagnosis, 80% (16/20) with adrenal gland tumor.