CHI3L1 and neoplasm: We then calculated the tumor immune related scores between CHI3L1high and CHI3L1low groups in TCGA cohort suing “ESTIMATE” R package, tumor immune dysfunction and exclusion (TIDE) portal, and 18 immune related genes 25, and found that patients with higher CHI3L1 expression exhibited a phenotype with higher tumor inflammation signature (TIS) score, immune score, estimate score, stromal score and dysfunction score, along with lower tumor purity and exclusion score (Figure 5F).