CHI3L1 and neoplasm: As CHI3L1 had been proved to be a biomarker of inflammatory and neoplastic disease 21, we plotted ROC curves and calculated the area under the curve (AUC) to estimate the diagnostic performance of CHI3L1 in glioma in TCGA and CGGA, and the AUC value (one year) were up to 0.852 and 0.741, respectively (Figure 1O-P).