CHI3L1 and neoplasm: TNFɑ signaling via the NF-κB pathway was significantly enriched in tumor sites (Figure 2I), and the enrichment score of NF-κB pathway was higher in the CHI3L1high group than that of the CHI3L1low group (patients were divided into CHI3L1high and CHI3L1low groups based on a median cut-off of the CHI3L1 expression) (Figure 2J).