However, it is important to note that several cell lines were unresponsive to this CDCP1 targeted ADC despite having anti-CDCP1 antibodies bound/cell levels well above the threshold including kidney cancer A498, 786-O, and ACHN cells, potentially indicating that this type of cancer has a mechanism to avoid ch10D7-MMAE cytotoxicity (Figure 3D right). The gene discussed is CDCP1; the disease is cancer.