Cells with levels below this threshold are largely unresponsive to ch10D7, although several cell lines with expression above this threshold were also resistant to ch10D7-MMAE, including three clear cell renal cell carcinoma (ccRCC) cell lines, 786-O, A498 and ACHN, which display higher levels of cell surface CDCP1 than the threshold (Figure 3D). This evidence concerns the gene CDCP1 and nonpapillary renal cell carcinoma.