ch10D7-89Zr was effective at detecting CDCP1-expressing PDAC xenografts in mice, and ch10D7-MMAE displayed robust anti-tumor effects in vivo against xenografts of PDAC, and ovarian and colon cancer, significantly prolonging mouse survival in comparison with controls including three chemotherapeutic agents widely used clinically. Here, CDCP1 is linked to colonic neoplasm.