Liu et al. used Ti3C2 nanosheets as carriers to chemically conjugated with glucose oxidase (GOX) and chloroperoxidase (CPO) and load deoxygenation-activated prodrug tirapazamine (TPZ) to prepare a cascaded-enzyme nanoreactor Ti3C2- GOX - CPO / TPZ (TGCT), which was finally encapsulated into tumor cell membrane carriers with high expression of CD47 (meTGCT). Here, CPO is linked to neoplasm.