With high expression of FAP and/or αvβ3 being described in multiple tumor types, our preclinical success prompted us to conduct the preliminary first-in-human study, which suggests that [68Ga]Ga-FAPI-RGD can be used for visualization of a wide spectrum of tumors, including those of FAP-/αvβ3+, FAP+/ αvβ3-, and FAP+/αvβ3+. Here, FAP is linked to neoplasm.