Although unknown, it can be assumed that the substrates of zDHHC6 are not only AEG-1 in HCC, truly, previous studies did identify several substrates of zDHHC6, e.g. CANX on mitochondria 57, NRAS, gp78 and IP3R on endoplasmic reticulum in different circumstances 58-60. Here, ZDHHC6 is linked to hepatocellular carcinoma.