CDKN1A and hepatocellular carcinoma: The overexpression of AEG-1 or SND1, an AEG-1 interacting protein, in liver cancer cells significantly enhances the activity of RNA-induced silencing complex (RISC), which may increase the degradation of tumor suppressor messenger RNAs e.g. PTEN, CDKN1A (p21), SPRY2, and TGFBR2 and therefore promotes the occurrence and development of HCC 6.