AEG-1 is a multifaceted protein involved in not only growth and proliferation, angiogenesis, metastasis and chemoresistance, engaging very complicated signaling cascades, for example, AEG-1 mediated PI3K/AKT induction activates a series of phosphorylation processes, which promotes c-MYC activity, inactivates GSK3β and more production of AEG-1, while inhibits the activity and the production of p53, may accompanied by suppressing the starvation-dependent p21/mda-6 expression and activating MDM2, with the consequence of stimulating tumor progression 49. This evidence concerns the gene CDKN1A and neoplasm.