However, considering the facts that the deletion of Zdhhc6 (Figure 4) virtually phenocopies that of the AEG-1C75A (Figure 2) in the DEN-induced HCC mouse model, and AEG-1 is a proven substrate of zDHHC6 (Figure 3A-F), we tend to conceive that the zDHHC6-AEG-1 axis plays vital roles in regulating HCC progression, although we should not rule out other possibilities. Here, ZDHHC6 is linked to hepatocellular carcinoma.