Although unknown, it can be assumed that the substrates of zDHHC6 are not only AEG-1 in HCC, truly, previous studies did identify several substrates of zDHHC6, e.g. CANX on mitochondria 57, NRAS, gp78 and IP3R on endoplasmic reticulum in different circumstances 58-60. The gene discussed is CANX; the disease is hepatocellular carcinoma.