MTDH and hepatocellular carcinoma: As previously reported that the protein level of AEG-1 is often found upregulated in different type of tumors 32, 33, consistently, here we showed that AEG-1 expression is also augmented in HCC tumor tissues as compared to their adjacent normal tissues (Figure 1H), indicating that increased levels of AEG-1 might promote HCC tumorigenesis.