For examples, the BRAF inhibitor vemurafenib upregulates EMT gene expression in BRAF or NRAS mutated melanoma cells and promotes cell invasion and metastasis 50; the BRAF inhibitor PLX4032 enhances EMT in BRAF inhibitor-resistant thyroid cancer cell line 8505C cells 51. The gene discussed is NRAS; the disease is thyroid gland carcinoma.