The mRNA profiles of anoikis-resistant HCC cells revealed the significant reduced leucine-rich repeat containing 7 (LRRC7) expressions since extracellular mature exosomal miR-25-5p directly targeted its 5' UTR, which facilitated the trans-endothelial migration of CTCs in a dose dependent manner 60. The gene discussed is LRRC7; the disease is hepatocellular carcinoma.