Our study also demonstrates that MEX3A directly suppresses terminal differentiation regulator KLF4. Supporting oncogenic function of MEX3A, KLF4 is downregulated in CRC and functions as tumor suppressor 44 and it inhibits WNT signaling activity in HCT116 colon cancer cells by competitively interacting with β-catenin 38, 39. Here, KLF4 is linked to colonic neoplasm.