The ability of NIR-PITs to eliminate EGFR- or HER2-expressing cancer cells have been used to treat multiple types of tumors, including brain 33, head and neck 34, 35, bladder 36-38, lung 39-42, ovarian 43-45, breast 46-50, esophageal 51, and gastrointestinal 52-56 cancers. This evidence concerns the gene ERBB2 and cancer.