The results showed that both the occurrence of CKD stage > 1 and albuminuria were negatively associated with Klotho when Klotho smaller than turning point (for whether CKD stage > 1, turning point K = 6.85, Klotho < K, OR = 0.44, p < 0.001; for albuminuria, turning point K = 6.84, Klotho < K, OR = 0.59, p < 0.001). This evidence concerns the gene KL and chronic kidney disease.