KL and chronic kidney disease: eGFR was positively associated with Klotho levels (β = 5.14, 95%CI 4.13–6.15, p < 0.001), while CKD risk was negatively correlated (stage ≧ 1, OR = 0.62, 95% CI 0.50–0.76, p < 0.001; stage ≧ 3, OR = 0.31, 95% CI 0.24–0.41, p < 0.001).