KL and chronic kidney disease: In fully adjusted model, the association was positive between Klotho and eGFR (β = 5.91, 95% CI 4.63–7.18, p < 0.001), and negative between Klotho and both of two stage of CKD (stage ≧ 1, OR = 0.59, 95% CI 0.48–0.72, p < 0.001; stage ≧ 3, OR = 0.34, 95% CI 0.26–0.44, p < 0.001).