KL and chronic kidney disease: In non-adjusted crude model, when log-transformed Klotho concentration increased 1 unit, eGFR was 7.77 mL/min/1.73m2 higher (p < 0.001), and the risk of CKD was lower (stage ≧ 1 decreased 47%, and stage ≧ 3 decreased 72%, both of p-values < 0.001).