To further verify the identified 7 key genes in MLL-R ALL, we detected the expression of PROM1, FLT3, CTGF, LGALS1, IGFBP7, ZNRF1, and RUNX2 between MLL-R ALL and MLL-G ALL in GSE68720 and GSE19475 datasets by using the R software. Here, CCN2 is linked to acute lymphoblastic leukemia.