As expected, in the present study, except for the observed promotive effect on cell apoptosis and cell cycle blockage of GBM tumors, we found that radiation, resveratrol, or cotreatment also effectively suppressed Cyclin D1, C-myc, and Survivin levels as well as the ratios of p-STAT3 (ser 727)/STAT3, p-STAT3 (tyr 705)/STAT3, and p-AKT/AKT and upregulated Bad, Cleaved Caspase-9, p-p53, and p-p21 levels in GBM tissues, suggesting that resveratrol triggered apoptosis by downregulating the AKT/STAT3 signaling pathway, thereby enhancing the effect of radiotherapy. The gene discussed is TP53; the disease is glioblastoma.