For example, Kinyamu et al. used genome-wide transcriptional profiling to demonstrate that RBP7 is positively regulated by estradiol (E2) in breast cancer cells [38]; Calvo et al. reported that blockers of estrogen receptors inhibited the expression of estradiol-modulated genes, including RBP7, in the mouse mammary gland [39]. This evidence concerns the gene ESR1 and breast cancer.