The top 50 significant genes that were positively and negatively correlated with RBP7 were selected as heat maps (Supplementary Figures 2A and 2B) in which RBP7 displayed a strong positive association with the expression of FAM107A (R = 0.4767, pvalue =4.252e-01), GPIHBP1 (R = 0.4757, pvalue =8.560e-63), and FXYD1 (R = 0.4756, pvalue =9.258e-63).Remarkably, the top 50 negatively coexpressed genes had a high probability of being high-risk markers in breast cancer, of which 15 genes had significantly high HRs (pvalue<0.05). The gene discussed is GPIHBP1; the disease is breast carcinoma.