AIM2 and neoplasm: Recently, some kinds of inflammasomes were identified to be correlated to tumor immune microenvironment (TIME), including nucleotide-binding oligomerization domain–like receptor (NLR) proteins family pyrin domain containing 1 (NLRP1), NLR family pyrin domain containing 3 (NLRP3), and absent in melanoma 2 (AIM2) (11, 17).