LPS specifically activates Toll-like receptor 4 (TLR4) and CD14, which are widely expressed by CD8+ T cells, macrophages, natural killer (NK) cells and Dendritic cells (DCs), and initiates tumor-suppressive downstream signaling cascades mainly through myeloid differentiation primary response 88 (MYD88), such as the secretion of proinflammatory cytokines and cytotoxic factors, as well as the formation of inflammasome. The gene discussed is TLR4; the disease is neoplasm.