Generally, the high ICOS expression cohort showed high CNA frequency, with more deletion in tumor-suppressive genes, including CDKN2A, CDKN2B, MTAP, MLLT3, and PTEN, while with more amplification in oncogenic genes, including EGFR, CDK4, FIP1L1, PDGFRA, CHIC2, PIK3C2B, KIT, MDM4, MBD6, and DDIT3. This evidence concerns the gene MDM4 and neoplasm.