High ICOS expression level was found to be significantly correlated with high amplification in multiple oncogenic drivers, such as EGFR, PDGFRA, CDK4, PIK3C2B, and MDM4 (47), and with more frequent deletions in tumor-suppressing genes like PTEN, CDKN2A, and CDKN2B (48). This evidence concerns the gene CDKN2A and neoplasm.