Regarding the variation in metabolic pathways between CD5+ and CD5− non-DE DLBCL, as revealed by GSEA, upregulation of lipid metabolic pathways, including the PPAR signaling pathway, the ATP-binding cassette transporter pathway, ether lipid metabolism, the fatty acid metabolism pathway, and arachidonic acid metabolism, was observed in CD5+ patients. The gene discussed is CD5; the disease is diffuse large B-cell lymphoma.