HMGB3 and neoplasm: Meanwhile, hypoxic CAFs-derived exosomes could reverse 5-FU-induced HMGB3, c-Myc, and β-catenin downregulation in tumor tissues, suggesting that hypoxic CAFs-derived exosomes could reduce the sensitivity of CRC cells to 5-FU via activating HMGB3/β-catenin/c-Myc signaling.