IDH2 and neoplasm: Given the inherent tumor heterogeneity in histopathological tissues and the universal availability of MRI, we expected the use of machine learning classifiers of the tumor texture features extracted from multiparametric magnetic resonance imaging (MRI) in a large cohort of GBM patients to subclassify them based on the IDH status as confirmed by immunohistochemistry and/or gene sequencing as the gold standard.