In agreement with this, pan-cancer studies have shown evidence of positive selection for chromosomal imbalances associated with oncogenic driver mutations – including BRAF - as well as negative selection for imbalances associated with mutations in haplo-essential driver genes such as the Splicing Factor 3b Subunit 1 - SF3B1, (102) a gene frequently mutated in uveal melanomas as well as vulvovaginal and anorectal mucosal melanomas (103). The gene discussed is SF3B1; the disease is cancer.