PLK4 and melanoma: Using immunofluorescence to visualize 79 melanoma tissue microarrays, Denu et al. (81) reported that CA is prevalent in melanoma and arises mainly from centriole overduplication (as opposed to cytokinesis failure or other mechanisms of failed mitosis), albeit a lack of association of expression of Polo-like Kinase 4 - PLK4, a main driver of centriole duplication – with CA.