Studies implicating BRAF V600E mutation with SAC dysregulation, loss of CDKN2 with centrosome amplification and KIT K642E mutation with replication stress prompt the characterization of aneuploidy and tetraploidy on large cutaneous (4, 123) and mucosal melanoma cohorts (40) segregated by mutational background, including the TP53 tumor suppressor. Here, BRAF is linked to mucosal melanoma.